First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease

نویسندگان

  • Jenny Dörnemann
  • Chiara Burzio
  • Axelle Ronsse
  • Armand Sprecher
  • Hilde De Clerck
  • Michel Van Herp
  • Marie-Claire Kolié
  • Vesselina Yosifiva
  • Severine Caluwaerts
  • Anita K. McElroy
  • Annick Antierens
چکیده

A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.

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عنوان ژورنال:

دوره 215  شماره 

صفحات  -

تاریخ انتشار 2017